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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Lupeol, Paclitaxel
Phytochemical Name Lupeol (PubChem CID: 259846 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Paclitaxel
Adverse Reactions Bronchospasmodic dyspnoea, hypotension, peripheral neuropathy and bone, joint and muscle aches and pains. This was inferred cold nature anticancer drug.
Recommendations Hot: Dimocarpus longan; Terminalia chebula; Astragalus membranaceus; Lycopodium japonicum
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 1025
Ref_1
Pair Name Lupeol, Paclitaxel
Disease Info [ICD-11: 2B66.0] Oral squamous cell carcinoma Investigative
Biological Phenomena Induction-->Vasculogenic mimicry
Gene Regulation Down-regulation Expression HIF1A hsa3091
Down-regulation Expression CDH5 hsa1003
Down-regulation Expression EPHA2 hsa1969
Down-regulation Expression MMP2 hsa4313
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CDH1 hsa999
Down-regulation Expression VIM hsa7431
Down-regulation Expression SNAI1 hsa6615
Down-regulation Expression TWIST1 hsa7291
Down-regulation Expression PROM1 hsa8842
In Vitro Model UPCI-SCC-154 Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_2230
UPCI-SCC-090 Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_1899
Result Our findings elucidated mechanistic underpinning of hypoxia induced Laminin-5γ2 driven VM formation highlighting that Lupeol-Paclitaxel combination may serve as novel therapeutic intervention in perturbation of VM in human OSCC.
03. Reference
No. Title Href
1 Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer. J Cell Commun Signal. 2023 Sep;17(3):591-608. doi: 10.1007/s12079-022-00693-z. Click
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